John C. Bischof 教授 特別講演会

日時: 2006年03月17日(金) 15:00〜16:00
場所: 京都大学 工学部物理系校舎 2階 211会議室
講演者: John C. Bischof (ミネソタ大学教授, Society for Cryobiology 会長)
講演題目: Biomedical Heat Transfer: Multiscale molecular, cellular and tissue level phenomenon
講演要旨: Heat transfer plays a crucial role in many biomedical applications in cryobiology (biopreservation and cryosurgery) and hyperthermic biology (thermal therapies). In these applications, thermal excursions are used to selectively preserve or destroy cells and tissues. Biopreservation is an enabling technology to many biomedical fields including cell and tissue banking, cell therapeutics, tissue engineering, organ transplantation and assisted reproductive technologies. Thermal therapies including cryosurgery are increasingly important in all surgical sub-specialties for minimally invasive thermal destruction of tissues for cancer and cardiovascular disease treatment. In this talk work predominantly from our lab will be reviewed focusing on cellular and molecular phenomena that are important in defining outcomes of both cryobiological and hyperthermic biomedical applications. During these applications microscale cellular phenomena depend on the heat transfer process, such as cellular dehydration, intracellular ice formation, and membrane hyperpermeability and blebbing which are all mechanistically linked to viability change. Molecular and nanoscale events include lipid oxidation, phase change and segregation as well as protein denaturation which are mechanistically linked to viability changes. Function can also be affected as for example both heating and freezing changes to collagen can change biomechanical properties, especially in some cardiovascular tissues. In addition, gene regulated events (inflammation and apoptosis), often in response to thermally triggered molecular changes, have recently been shown to increase thermal destruction of cells. Finally, recent work will be reviewed with iron oxide and gold nanoparticles showing their dramatic potential to both enhance and control thermal therapy outcomes through adjuvant (drug) delivery, tomographic visualization and inductive heating within the body.

京都大学大学院 工学研究科 機械理工学専攻 マイクロエンジニアリング専攻 航空宇宙工学専攻
情報学研究科 複雑系科学専攻
京都大学 国際融合創造センター
拠点リーダー 土屋和雄(工学研究科・航空宇宙工学専攻)
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